Update on emerging drugs for sarcopenia - Age-related muscle wasting

GS Lynch

Journal article

Update on emerging drugs for sarcopenia - Age-related muscle wasting

GS Lynch

Expert Opinion on Emerging Drugs | Published : 2008

DOI: 10.1517/14728210802544476

Abstract

Sarcopenia - the progressive loss of muscle mass with advancing age is characterised by a deterioration of muscle quantity and quality leading to a gradual slowing of movement and a decline in strength and power. Sarcopenia is a highly significant public health problem. Frail elders often require assistance for accomplishing even basic tasks of independent living, and they are also at increased risk of serious injury from sudden falls and subsequent fractures. Since these age-related changes are largely attributed to the complex interaction of factors affecting neuromuscular transmission, muscle architecture, fibre composition, excitation-contraction coupling, and metabolism, the mechanisms ..

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University of Melbourne Researchers

Gordon Lynch Author

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Grants

Awarded by Australian Research Council Discovery

Awarded by National Health and Medical Research Council of Australia

Awarded by Muscular Dystrophy Association (USA)

Awarded by Australian Research Council

Funding Acknowledgements

The author is grateful for research grant support from the Australian Research Council Discovery-Project funding scheme (DP0665071, DP0772781), National Health and Medical Research Council of Australia (454561, 509313, 566818, 566820), Muscular Dystrophy Association (USA, 4167), Association Francaise contre les Myopathies, Pfizer, Inc. (USA), E Hoffmann-La Roche Ltd. (Switzerland) and Merck & Co., Inc. (USA).